High fat feeding in cardiomyocyte-restricted PPARδ knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes

Peroxisome proliferator activated receptor δ (PPARδ) is an essential determinant of basal myocardial fatty acid oxidation (FAO) and bioenergetics. We wished to determine whether increased lipid loading affects the PPARδ deficient heart in transcriptional regulation of FAO and in the development of c...

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Bibliographic Details
Main Authors:	Li, Yuquan, Cheng, Lihong, Qin, Qianhong, Liu, Jian, Lo, Woo-kuen, Brako, Lowrence A., Yang, Qinglin
Format:	Artigo
Language:	Inglês
Published:	2009
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2766590/ https://ncbi.nlm.nih.gov/pubmed/19595695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.07.001
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High fat feeding in cardiomyocyte-restricted PPARδ knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes

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