RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells

Antibody diversification by somatic hypermutation, gene conversion, and class switch recombination is completely dependent on activation-induced cytidine deaminase (AID). A recent report showing induction of DNA mutations in Escherichia coli by overexpression of AID, Apobec-1, and related members of...

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Bibliografiska uppgifter
Huvudupphovsmän: Eto, Tomonori, Kinoshita, Kazuo, Yoshikawa, Kiyotsugu, Muramatsu, Masamichi, Honjo, Tasuku
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2003
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC240715/
https://ncbi.nlm.nih.gov/pubmed/14559972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2135587100
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