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Complementary dimerization of microtubule-associated tau protein: Implications for microtubule bundling and tau-mediated pathogenesis

Tau is an intrinsically unstructured microtubule (MT)-associated protein capable of binding to and organizing MTs into evenly spaced parallel assemblies known as “MT bundles.” How tau achieves MT bundling is enigmatic because each tau molecule possesses only one MT-binding region. To dissect this co...

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Bibliografiske detaljer
Main Authors: Rosenberg, Kenneth J., Ross, Jennifer L., Feinstein, H. Eric, Feinstein, Stuart C., Israelachvili, Jacob
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396711/
https://ncbi.nlm.nih.gov/pubmed/18495933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802036105
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