DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer

Gene transfer has been used to correct inherited immunodeficiencies, but in several patients integration of therapeutic retroviral vectors activated proto-oncogenes and caused leukemia. Here, we describe improved methods for characterizing integration site populations from gene transfer studies usin...

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Autori principali: Wang, Gary P., Garrigue, Alexandrine, Ciuffi, Angela, Ronen, Keshet, Leipzig, Jeremy, Berry, Charles, Lagresle-Peyrou, Chantal, Benjelloun, Fatine, Hacein-Bey-Abina, Salima, Fischer, Alain, Cavazzana-Calvo, Marina, Bushman, Frederic D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2008
Soggetti:
Methods Online
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396413/
https://ncbi.nlm.nih.gov/pubmed/18411205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn125
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