DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer

Gene transfer has been used to correct inherited immunodeficiencies, but in several patients integration of therapeutic retroviral vectors activated proto-oncogenes and caused leukemia. Here, we describe improved methods for characterizing integration site populations from gene transfer studies usin...

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Detalhes bibliográficos
Main Authors: Wang, Gary P., Garrigue, Alexandrine, Ciuffi, Angela, Ronen, Keshet, Leipzig, Jeremy, Berry, Charles, Lagresle-Peyrou, Chantal, Benjelloun, Fatine, Hacein-Bey-Abina, Salima, Fischer, Alain, Cavazzana-Calvo, Marina, Bushman, Frederic D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396413/
https://ncbi.nlm.nih.gov/pubmed/18411205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn125
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