DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer

Gene transfer has been used to correct inherited immunodeficiencies, but in several patients integration of therapeutic retroviral vectors activated proto-oncogenes and caused leukemia. Here, we describe improved methods for characterizing integration site populations from gene transfer studies usin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wang, Gary P., Garrigue, Alexandrine, Ciuffi, Angela, Ronen, Keshet, Leipzig, Jeremy, Berry, Charles, Lagresle-Peyrou, Chantal, Benjelloun, Fatine, Hacein-Bey-Abina, Salima, Fischer, Alain, Cavazzana-Calvo, Marina, Bushman, Frederic D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2008
Pynciau:
Methods Online
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396413/
https://ncbi.nlm.nih.gov/pubmed/18411205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn125
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