Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial

X-linked severe-combined immunodeficiency (SCID-X1) has been treated by therapeutic gene transfer using gammaretroviral vectors, but insertional activation of proto-oncogenes contributed to leukemia in some patients. Here we report a longitudinal study of gene-corrected progenitor cell populations f...

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Detalhes bibliográficos
Main Authors: Wang, Gary P., Berry, Charles C., Malani, Nirav, Leboulch, Philippe, Fischer, Alain, Hacein-Bey-Abina, Salima, Cavazzana-Calvo, Marina, Bushman, Frederic D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881494/
https://ncbi.nlm.nih.gov/pubmed/20228274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-257352
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