DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer

Gene transfer has been used to correct inherited immunodeficiencies, but in several patients integration of therapeutic retroviral vectors activated proto-oncogenes and caused leukemia. Here, we describe improved methods for characterizing integration site populations from gene transfer studies usin...

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Main Authors: Wang, Gary P., Garrigue, Alexandrine, Ciuffi, Angela, Ronen, Keshet, Leipzig, Jeremy, Berry, Charles, Lagresle-Peyrou, Chantal, Benjelloun, Fatine, Hacein-Bey-Abina, Salima, Fischer, Alain, Cavazzana-Calvo, Marina, Bushman, Frederic D.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2008
主題:
Methods Online
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396413/
https://ncbi.nlm.nih.gov/pubmed/18411205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn125
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