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Direct measurement of metal ion chelation in the active site of human ferrochelatase
The final step in heme biosynthesis, insertion of ferrous iron into protoporphyrin IX, is catalyzed by protoporphyrin IX ferrochelatase (E.C. 4.99.1.1). It is demonstrated that the pre-steady state human ferrochelatase (R115L) shows a stoichiometric burst of product formation and substrate consumpti...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2396339/ https://ncbi.nlm.nih.gov/pubmed/17566985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi602418e |
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