Deletion of Ptpn11 (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Erk/MAPK and RhoA Signaling Pathways

BACKGROUND: Heart failure is the leading cause of death in the U.S. By delineating the pathways that regulate cardiomyocyte function, the pathogenesis of cardiac disease can be better understood. Many cardiomyocyte signaling pathways activate protein-tyrosine kinases. However, the role of specific p...

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Hlavní autoři: Kontaridis, Maria I., Yang, Wentian, Bence, Kendra K., Cullen, Darragh, Wang, Bo, Bodyak, Natalya, Ke, Qingen, Hinek, Aleksander, Kang, Peter M., Liao, Ronglih, Neel, Benjamin G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394674/
https://ncbi.nlm.nih.gov/pubmed/18316486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.728865
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