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Regulation of RhoA-dependent ROCKII activation by Shp2

Contractile forces mediated by RhoA and Rho kinase (ROCK) are required for a variety of cellular processes, including cell adhesion. In this study, we show that RhoA-dependent ROCKII activation is negatively regulated by phosphorylation at a conserved tyrosine residue (Y722) in the coiled-coil domai...

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Detalhes bibliográficos
Main Authors: Lee, Hsiao-Hui, Chang, Zee-Fen
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426933/
https://ncbi.nlm.nih.gov/pubmed/18559669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200710187
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