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Deletion of Ptpn11 (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Erk/MAPK and RhoA Signaling Pathways
BACKGROUND: Heart failure is the leading cause of death in the U.S. By delineating the pathways that regulate cardiomyocyte function, the pathogenesis of cardiac disease can be better understood. Many cardiomyocyte signaling pathways activate protein-tyrosine kinases. However, the role of specific p...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2394674/ https://ncbi.nlm.nih.gov/pubmed/18316486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.728865 |
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