MATRIX METALLOPROTEINASE-ACTIVATED ANTHRAX LETHAL TOXIN DEMONSTRATES HIGH POTENCY IN TARGETING TUMOR VASCULATURE

Anthrax lethal toxin (LT), a virulence factor secreted by Bacillus anthracis, is selectively toxic to human melanomas with the BRAF V600E activating mutation due to its proteolytic activities toward the mitogen-activated protein kinase kinases (MEKs). To develop LT variants with lower in vivo toxici...

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Hlavní autoři: Liu, Shihui, Wang, Hailun, Currie, Brooke M., Molinolo, Alfredo, Leung, Howard J., Moayeri, Mahtab, Basile, John R., Alfano, Randall W., Gutkind, J. Silvio, Frankel, Arthur E., Bugge, Thomas H., Leppla, Stephen H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394502/
https://ncbi.nlm.nih.gov/pubmed/17974567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707419200
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