Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis

Solid tumor growth is dependent on angiogenesis, the formation of neovasculature from existing vessels. Endothelial activation of the ERK1/2, JNK, and p38 mitogen activated protein kinase (MAPK) pathways is central to this process, and thus presents an attractive target for the development of angiog...

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Bibliografiske detaljer
Main Authors: Alfano, Randall W., Leppla, Stephen H., Liu, Shihui, Bugge, Thomas H., Meininger, Cynthia J., Lairmore, Terry C., Mulne, Arlynn F., Davis, Samuel H., Duesbery, Nicholas S., Frankel, Arthur E.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676781/
https://ncbi.nlm.nih.gov/pubmed/19372576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0451
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