Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis

Solid tumor growth is dependent on angiogenesis, the formation of neovasculature from existing vessels. Endothelial activation of the ERK1/2, JNK, and p38 mitogen activated protein kinase (MAPK) pathways is central to this process, and thus presents an attractive target for the development of angiog...

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Main Authors: Alfano, Randall W., Leppla, Stephen H., Liu, Shihui, Bugge, Thomas H., Meininger, Cynthia J., Lairmore, Terry C., Mulne, Arlynn F., Davis, Samuel H., Duesbery, Nicholas S., Frankel, Arthur E.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676781/
https://ncbi.nlm.nih.gov/pubmed/19372576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0451
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