Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma

Patients with anaplastic thyroid carcinoma (ATC) typically succumb to their disease months after diagnosis despite aggressive therapy. A large percentage of ATCs have been shown to harbor the V600E B-Raf point mutation, leading to the constitutive activation of the mitogen-activated protein kinase (...

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Detalhes bibliográficos
Main Authors: Alfano, Randall W., Leppla, Stephen H., Liu, Shihui, Bugge, Thomas H., Ortiz, Janelle M., Lairmore, Terry C., Duesbery, Nicholas S., Mitchell, Ian C., Nwariaku, Fiemu, Frankel, Arthur E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806504/
https://ncbi.nlm.nih.gov/pubmed/20053778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0694
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