Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells

Anthrax Lethal Toxin (LeTx) demonstrates potent MAPK pathway inhibition and apoptosis in melanoma cells that harbor the activating V600E B-RAF mutation. LeTx is composed of two proteins, PA and LF. Uptake of the toxin into cells is dependent upon proteolytic activation of PA by the ubiquitously expr...

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Detaylı Bibliyografya
Asıl Yazarlar: Alfano, Randall W., Leppla, Stephen H., Liu, Shihui, Bugge, Thomas H., Herlyn, Meenhard, Smalley, Keiran S., Bromberg-White, Jennifer L., Duesbery, Nicholas S., Frankel, Arthur E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757055/
https://ncbi.nlm.nih.gov/pubmed/18483309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0024
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