Comparative lesion sequencing provides insights into tumor evolution

We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses suggest the following general conclusions about colorectal tumorigenesis: (i)...

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Detalhes bibliográficos
Main Authors: Jones, Siân, Chen, Wei-dong, Parmigiani, Giovanni, Diehl, Frank, Beerenwinkel, Niko, Antal, Tibor, Traulsen, Arne, Nowak, Martin A., Siegel, Christopher, Velculescu, Victor E., Kinzler, Kenneth W., Vogelstein, Bert, Willis, Joseph, Markowitz, Sanford D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2393770/
https://ncbi.nlm.nih.gov/pubmed/18337506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712345105
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