Comparative lesion sequencing provides insights into tumor evolution

We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses suggest the following general conclusions about colorectal tumorigenesis: (i)...

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Autori principali: Jones, Siân, Chen, Wei-dong, Parmigiani, Giovanni, Diehl, Frank, Beerenwinkel, Niko, Antal, Tibor, Traulsen, Arne, Nowak, Martin A., Siegel, Christopher, Velculescu, Victor E., Kinzler, Kenneth W., Vogelstein, Bert, Willis, Joseph, Markowitz, Sanford D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2393770/
https://ncbi.nlm.nih.gov/pubmed/18337506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712345105
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