Endocytosis is required for synaptic activity-dependent release of amyloid-β in vivo

Aggregation of amyloid-β (Aβ) peptide into soluble and insoluble forms within the brain extracellular space is central to the pathogenesis of Alzheimer’s disease. Full length amyloid precursor protein (APP) is endocytosed from the cell surface into endosomes where it is cleaved to produce Aβ. Aβ is...

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Main Authors: Cirrito, John R., Kang, Jae-Eun, Lee, Jiyeon, Stewart, Floy R., Verges, Deborah K., Silverio, Luz M., Bu, Guojun, Mennerick, Steven, Holtzman, David M.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2390913/
https://ncbi.nlm.nih.gov/pubmed/18400162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.02.003
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