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Endocytosis is required for synaptic activity-dependent release of amyloid-β in vivo
Aggregation of amyloid-β (Aβ) peptide into soluble and insoluble forms within the brain extracellular space is central to the pathogenesis of Alzheimer’s disease. Full length amyloid precursor protein (APP) is endocytosed from the cell surface into endosomes where it is cleaved to produce Aβ. Aβ is...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2390913/ https://ncbi.nlm.nih.gov/pubmed/18400162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.02.003 |
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