Endocytosis is required for synaptic activity-dependent release of amyloid-β in vivo

Aggregation of amyloid-β (Aβ) peptide into soluble and insoluble forms within the brain extracellular space is central to the pathogenesis of Alzheimer’s disease. Full length amyloid precursor protein (APP) is endocytosed from the cell surface into endosomes where it is cleaved to produce Aβ. Aβ is...

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Autori principali: Cirrito, John R., Kang, Jae-Eun, Lee, Jiyeon, Stewart, Floy R., Verges, Deborah K., Silverio, Luz M., Bu, Guojun, Mennerick, Steven, Holtzman, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2390913/
https://ncbi.nlm.nih.gov/pubmed/18400162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.02.003
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