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In vivo consequences of deleting EGF repeats 8–12 including the ligand binding domain of mouse Notch1
BACKGROUND: Notch signaling is highly conserved in the metazoa and is critical for many cell fate decisions. Notch activation occurs following ligand binding to Notch extracellular domain. In vitro binding assays have identified epidermal growth factor (EGF) repeats 11 and 12 as the ligand binding d...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2390518/ https://ncbi.nlm.nih.gov/pubmed/18445292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-8-48 |
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