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The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development

Mechanisms by which the extracellular domain of Notch1 controls Notch1 signaling are not well defined. Here, we show that the O-fucose glycan in the Notch1 ligand-binding domain regulates the strength of Notch1 signaling during embryogenesis, postweaning growth, and T cell development in the mouse....

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Bibliografiske detaljer
Main Authors: Ge, Changhui, Stanley, Pamela
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234180/
https://ncbi.nlm.nih.gov/pubmed/18227520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702846105
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