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The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development
Mechanisms by which the extracellular domain of Notch1 controls Notch1 signaling are not well defined. Here, we show that the O-fucose glycan in the Notch1 ligand-binding domain regulates the strength of Notch1 signaling during embryogenesis, postweaning growth, and T cell development in the mouse....
Gorde:
| Egile Nagusiak: | , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2008
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234180/ https://ncbi.nlm.nih.gov/pubmed/18227520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702846105 |
| Etiketak: |
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