Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling

Mammalian Notch receptors contain 29–36 epidermal growth factor (EGF)-like repeats that may be modified by protein O-fucosyltransferase 1 (Pofut1), an essential component of the canonical Notch signaling pathway. The Drosophila orthologue Ofut1 is proposed to function as both a chaperone required fo...

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Détails bibliographiques
Auteurs principaux: Stahl, Mark, Uemura, Kazuhide, Ge, Changhui, Shi, Shaolin, Tashima, Yuko, Stanley, Pamela
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2008
Sujets:
Molecular Basis of Cell and Developmental Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376238/
https://ncbi.nlm.nih.gov/pubmed/18347015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802027200
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