O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

The glycosyltransferase EOGT transfers O-GlcNAc to a consensus site in epidermal growth factor-like (EGF) repeats of a limited number of secreted and membrane proteins, including Notch receptors. In EOGT-deficient cells, the binding of DLL1 and DLL4, but not JAG1, canonical Notch ligands was reduced...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Sawaguchi, Shogo, Varshney, Shweta, Ogawa, Mitsutaka, Sakaidani, Yuta, Yagi, Hirokazu, Takeshita, Kyosuke, Murohara, Toyoaki, Kato, Koichi, Sundaram, Subha, Stanley, Pamela, Okajima, Tetsuya
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388531/
https://ncbi.nlm.nih.gov/pubmed/28395734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24419
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