Lataa...
O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals
The glycosyltransferase EOGT transfers O-GlcNAc to a consensus site in epidermal growth factor-like (EGF) repeats of a limited number of secreted and membrane proteins, including Notch receptors. In EOGT-deficient cells, the binding of DLL1 and DLL4, but not JAG1, canonical Notch ligands was reduced...
Tallennettuna:
| Julkaisussa: | eLife |
|---|---|
| Päätekijät: | , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
eLife Sciences Publications, Ltd
2017
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5388531/ https://ncbi.nlm.nih.gov/pubmed/28395734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24419 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|