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The EGF Repeat-Specific O-GlcNAc-Transferase Eogt Interacts with Notch Signaling and Pyrimidine Metabolism Pathways in Drosophila

The O-GlcNAc transferase Eogt modifies EGF repeats in proteins that transit the secretory pathway, including Dumpy and Notch. In this paper, we show that the Notch ligands Delta and Serrate are also substrates of Eogt, that mutation of a putative UDP-GlcNAc binding DXD motif greatly reduces enzyme a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Müller, Reto, Jenny, Andreas, Stanley, Pamela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650022/
https://ncbi.nlm.nih.gov/pubmed/23671640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062835
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