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Importance of Hydrogen Bonding for Efficiency and Specificity of the Human Mitochondrial DNA Polymerase
To assess the contribution to discrimination afforded by base pair hydrogen bonding during DNA replication by the human mitochondrial DNA polymerase, we examined nucleoside mimics lacking hydrogen bond forming capability but retaining the overall steric shape of the natural nucleotide. We employed o...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2386926/ https://ncbi.nlm.nih.gov/pubmed/17650502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M705007200 |
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