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Base Pair Hydrogen Bonds Are Essential for Proofreading Selectivity by the Human Mitochondrial DNA Polymerase
We have characterized the role of Watson-Crick hydrogen bonding in the 3′-terminal base pair on the 3′-5′ exonuclease activity of the human mitochondrial DNA polymerase. Nonpolar nucleoside analogs of thymidine (dF) and deoxyadenosine (dQ) were used to eliminate hydrogen bonds while maintaining base...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2386942/ https://ncbi.nlm.nih.gov/pubmed/17650503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M705006200 |
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