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Importance of Hydrogen Bonding for Efficiency and Specificity of the Human Mitochondrial DNA Polymerase
To assess the contribution to discrimination afforded by base pair hydrogen bonding during DNA replication by the human mitochondrial DNA polymerase, we examined nucleoside mimics lacking hydrogen bond forming capability but retaining the overall steric shape of the natural nucleotide. We employed o...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2386926/ https://ncbi.nlm.nih.gov/pubmed/17650502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M705007200 |
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