Importance of Hydrogen Bonding for Efficiency and Specificity of the Human Mitochondrial DNA Polymerase

To assess the contribution to discrimination afforded by base pair hydrogen bonding during DNA replication by the human mitochondrial DNA polymerase, we examined nucleoside mimics lacking hydrogen bond forming capability but retaining the overall steric shape of the natural nucleotide. We employed o...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lee, Harold R., Helquist, Sandra A., Kool, Eric T., Johnson, Kenneth A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2008
Gaiak:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386926/
https://ncbi.nlm.nih.gov/pubmed/17650502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M705007200
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