Aberrant IgA1 Glycosylation Is Inherited in Familial and Sporadic IgA Nephropathy

IgA nephropathy (IgAN) is a complex trait determined by genetic and environmental factors. Most IgAN patients exhibit a characteristic undergalactosylation of the O-glycans of the IgA1 hinge region, which promotes formation and glomerular deposition of immune complexes. It is not known whether this...

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Autori principali: Gharavi, Ali G., Moldoveanu, Zina, Wyatt, Robert J., Barker, Catherine V., Woodford, Susan Y., Lifton, Richard P., Mestecky, Jiri, Novak, Jan, Julian, Bruce A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2008
Soggetti:
Clinical Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386728/
https://ncbi.nlm.nih.gov/pubmed/18272841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007091052
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