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IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1
Aberrant glycosylation of IgA1 plays an essential role in the pathogenesis of IgA nephropathy. This abnormality is manifested by a deficiency of galactose in the hinge-region O-linked glycans of IgA1. Biosynthesis of these glycans occurs in a stepwise fashion beginning with the addition of N-acetylg...
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Main Authors: | , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Clinical Investigation
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2157566/ https://ncbi.nlm.nih.gov/pubmed/18172551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33189 |
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