IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1

Aberrant glycosylation of IgA1 plays an essential role in the pathogenesis of IgA nephropathy. This abnormality is manifested by a deficiency of galactose in the hinge-region O-linked glycans of IgA1. Biosynthesis of these glycans occurs in a stepwise fashion beginning with the addition of N-acetylg...

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Bibliografiske detaljer
Main Authors: Suzuki, Hitoshi, Moldoveanu, Zina, Hall, Stacy, Brown, Rhubell, Vu, Huong L., Novak, Lea, Julian, Bruce A., Tomana, Milan, Wyatt, Robert J., Edberg, Jeffrey C., Alarcón, Graciela S., Kimberly, Robert P., Tomino, Yasuhiko, Mestecky, Jiri, Novak, Jan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2157566/
https://ncbi.nlm.nih.gov/pubmed/18172551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33189
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