Identification and characterization of CMP-NeuAc:GalNAc-IgA1 α2,6-sialyltransferase in IgA1-producing cells

Glycosylation defects occur in several human diseases. In IgA nephropathy, IgA1 contains O-glycans that are galactose-deficient and consist mostly of core 1 α2,6 sialylated N-acetylgalactosamine, a configuration suspected to prevent β1,3 galactosylation. We confirmed the same aberrancy in IgA1 secre...

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Hauptverfasser: Raska, Milan, Moldoveanu, Zina, Suzuki, Hitoshi, Brown, Rhubell, Kulhavy, Rose, Andrasi, Judit, Hall, Stacy, Vu, Huong L., Carlsson, Frederic, Lindahl, Gunnar, Tomana, Milan, Julian, Bruce A., Wyatt, Robert J., Mestecky, Jiri, Novak, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1995659/
https://ncbi.nlm.nih.gov/pubmed/17418236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.03.002
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