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IgA glycosylation and IgA immune complexes in the pathogenesis of IgA Nephropathy

Circulating immune complexes containing aberrantly glycosylated IgA1 play a pivotal role in the pathogenesis of IgAN. A portion of IgA1 secreted by IgA1-producing cells in patients with IgAN is galactose-deficient and consequently recognized by anti-glycan IgG or IgA1 antibodies. Some of the resulta...

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Detalhes bibliográficos
Main Authors: Novak, Jan, Julian, Bruce A., Tomana, Milan, Mestecky, Jiri
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2241661/
https://ncbi.nlm.nih.gov/pubmed/18222349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semnephrol.2007.10.009
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