Role of Aberrant Glycosylation of IgA1 Molecules in the Pathogenesis of IgA Nephropathy

Studies of the properties of immune complexes (IC) in the circulation, urine, and mesangium of IgA nephropathy (IgAN) patients have provided data relevant to the pathogenesis of this disease. IC contain predominantly polymeric IgA1 molecules which are deficient in galactose (Gal) residues on O-linke...

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Main Authors: Mestecky, J., Tomana, M., Moldoveanu, Z., Julian, B.A., Suzuki, H., Matousovic, K., Renfrow, M.B., Novak, L., Wyatt, R.J., Novak, J.
Format: Artigo
Jezik:Inglês
Izdano: S. Karger AG 2008
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821435/
https://ncbi.nlm.nih.gov/pubmed/18182777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000112922
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