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IgA glycosylation and IgA immune complexes in the pathogenesis of IgA Nephropathy
Circulating immune complexes containing aberrantly glycosylated IgA1 play a pivotal role in the pathogenesis of IgAN. A portion of IgA1 secreted by IgA1-producing cells in patients with IgAN is galactose-deficient and consequently recognized by anti-glycan IgG or IgA1 antibodies. Some of the resulta...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2241661/ https://ncbi.nlm.nih.gov/pubmed/18222349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semnephrol.2007.10.009 |
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