In vitro-generated immune complexes containing galactose-deficient IgA1 stimulate proliferation of mesangial cells

IgA nephropathy (IgAN) patients have elevated serum levels of immune complexes consisting of IgA1 with galactose-deficient hinge-region O-glycans (Gd-IgA1) and anti-glycan IgG. These immune complexes deposit in the kidney and activate mesangial cells. To confirm that the activity of these immune com...

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Main Authors: Yanagihara, Takeshi, Brown, Rhubell, Hall, Stacy, Moldoveanu, Zina, Goepfert, Alice, Tomana, Milan, Julian, Bruce A., Mestecky, Jiri, Novak, Jan
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775378/
https://ncbi.nlm.nih.gov/pubmed/24052934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.rinim.2012.08.002
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