Recent Insights in Islet Amyloid Polypeptide-Induced Membrane Disruption and Its Role in β-Cell Death in Type 2 Diabetes Mellitus

The presence of fibrillar protein deposits (amyloid) of human islet amyloid polypeptide (hIAPP) in the pancreatic islets of Langerhans is thought to be related to death of the insulin-producing islet β-cells in type 2 diabetes mellitus (DM2). The mechanism of hIAPP-induced β-cell death is not unders...

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Bibliographische Detailangaben
Hauptverfasser: Khemtémourian, Lucie, Antoinette Killian, J., Höppener, Jo W. M., Engel, Maarten F. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2008
Schlagworte:
Review Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377315/
https://ncbi.nlm.nih.gov/pubmed/18483616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/421287
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