Recent Insights in Islet Amyloid Polypeptide-Induced Membrane Disruption and Its Role in β-Cell Death in Type 2 Diabetes Mellitus

The presence of fibrillar protein deposits (amyloid) of human islet amyloid polypeptide (hIAPP) in the pancreatic islets of Langerhans is thought to be related to death of the insulin-producing islet β-cells in type 2 diabetes mellitus (DM2). The mechanism of hIAPP-induced β-cell death is not unders...

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Hlavní autoři: Khemtémourian, Lucie, Antoinette Killian, J., Höppener, Jo W. M., Engel, Maarten F. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2008
Témata:
Review Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377315/
https://ncbi.nlm.nih.gov/pubmed/18483616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/421287
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