The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes

Human islet amyloid polypeptide (hIAPP) forms amyloid fibrils in pancreatic islets of patients with type 2 diabetes mellitus. It has been suggested that the N-terminal part, which contains a conserved intramolecular disulfide bond between residues 2 and 7, interacts with membranes, ultimately leadin...

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Hauptverfasser: Khemtémourian, Lucie, Engel, Maarten F. M., Kruijtzer, John A. W., Höppener, Jo W. M., Liskamp, Rob M. J., Killian, J. Antoinette
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2010
Schlagworte:
Biophysics Letter
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903700/
https://ncbi.nlm.nih.gov/pubmed/20052582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00249-009-0572-4
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