Recent Insights in Islet Amyloid Polypeptide-Induced Membrane Disruption and Its Role in β-Cell Death in Type 2 Diabetes Mellitus

The presence of fibrillar protein deposits (amyloid) of human islet amyloid polypeptide (hIAPP) in the pancreatic islets of Langerhans is thought to be related to death of the insulin-producing islet β-cells in type 2 diabetes mellitus (DM2). The mechanism of hIAPP-induced β-cell death is not unders...

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Detalhes bibliográficos
Main Authors: Khemtémourian, Lucie, Antoinette Killian, J., Höppener, Jo W. M., Engel, Maarten F. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2008
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377315/
https://ncbi.nlm.nih.gov/pubmed/18483616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/421287
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