PP2B and PP1α cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca(2+) signaling

The positive transcription elongation factor b (P-TEFb), consisting of Cdk9 and cyclin T, stimulates RNA polymerase II elongation and cotranscriptional pre-mRNA processing. To accommodate different growth conditions and transcriptional demands, a reservoir of P-TEFb is kept in an inactive state in t...

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Detalhes bibliográficos
Main Authors: Chen, Ruichuan, Liu, Min, Li, Huan, Xue, Yuhua, Ramey, Wanichaya N., He, Nanhai, Ai, Nanping, Luo, Haohong, Zhu, Ying, Zhou, Nan, Zhou, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377190/
https://ncbi.nlm.nih.gov/pubmed/18483222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1636008
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