Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb

Release of RNA polymerase II (Pol II) from promoter-proximal pausing has emerged as a critical step regulating gene expression in multicellular organisms. The transition of Pol II into productive elongation requires the kinase activity of positive transcription elongation factor b (P-TEFb), which is...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: C. Quaresma, Alexandre J., Bugai, Andrii, Barboric, Matjaz
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027500/
https://ncbi.nlm.nih.gov/pubmed/27369380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw585
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