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Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation
The transition from transcription initiation into elongation is controlled by transcription factors, which recruit P-TEFb to promoters to phosphorylate RNA polymerase II. A fraction of P-TEFb is recruited as part of the inhibitory 7SK small nuclear ribonucleoprotein (snRNP), which inactivates the ki...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3882317/ https://ncbi.nlm.nih.gov/pubmed/24316072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.003 |
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