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Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation

The transition from transcription initiation into elongation is controlled by transcription factors, which recruit P-TEFb to promoters to phosphorylate RNA polymerase II. A fraction of P-TEFb is recruited as part of the inhibitory 7SK small nuclear ribonucleoprotein (snRNP), which inactivates the ki...

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Bibliografiske detaljer
Main Authors: McNamara, Ryan P., McCann, Jennifer L., Gudipaty, Swapna Aravind, D’Orso, Iván
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882317/
https://ncbi.nlm.nih.gov/pubmed/24316072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.003
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