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RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation
The transition from transcription initiation to elongation at the HIV-1 promoter is controlled by Tat, which recruits P-TEFb to TAR RNA to phosphorylate RNA polymerase II. It has long been unclear why the HIV-1 promoter is incompetent for elongation. We report that P-TEFb is recruited to the promote...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2921552/ https://ncbi.nlm.nih.gov/pubmed/20562857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1827 |
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