A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis

The general transcription factor P-TEFb stimulates RNA polymerase II elongation and co-transcriptional processing of pre-mRNA. Contributing to a functional equilibrium important for growth control, a reservoir of P-TEFb is maintained in an inactive snRNP where 7SK snRNA is a central scaffold. Here,...

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Udgivet i:Mol Cell
Main Authors: He, Nanhai, Jahchan, Nadine S., Hong, Eunmee, Li, Qiang, Bayfield, Mark A., Maraia, Richard J., Luo, Kunxin, Zhou, Qiang
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239424/
https://ncbi.nlm.nih.gov/pubmed/18249148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.01.003
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