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A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis
The general transcription factor P-TEFb stimulates RNA polymerase II elongation and co-transcriptional processing of pre-mRNA. Contributing to a functional equilibrium important for growth control, a reservoir of P-TEFb is maintained in an inactive snRNP where 7SK snRNA is a central scaffold. Here,...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6239424/ https://ncbi.nlm.nih.gov/pubmed/18249148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.01.003 |
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