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Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N-terminal domain

The HypF N-terminal domain has been found to convert readily from its native globular conformation into protein aggregates with the characteristics of amyloid fibrils associated with a variety of human diseases. This conversion was achieved by incubation at acidic pH or in the presence of moderate c...

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Bibliografiske detaljer
Main Authors: Chiti, Fabrizio, Bucciantini, Monica, Capanni, Cristina, Taddei, Niccolò, Dobson, Christopher M., Stefani, Massimo
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374049/
https://ncbi.nlm.nih.gov/pubmed/11714922
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