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Designing conditions for in vitro formation of amyloid protofilaments and fibrils

We have been able to convert a small α/β protein, acylphosphatase, from its soluble and native form into insoluble amyloid fibrils of the type observed in a range of pathological conditions. This was achieved by allowing slow growth in a solution containing moderate concentrations of trifluoroethano...

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Hlavní autoři: Chiti, Fabrizio, Webster, Paul, Taddei, Niccolò, Clark, Anne, Stefani, Massimo, Ramponi, Giampietro, Dobson, Christopher M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1999
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC22338/
https://ncbi.nlm.nih.gov/pubmed/10097081
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