Designing conditions for in vitro formation of amyloid protofilaments and fibrils

We have been able to convert a small α/β protein, acylphosphatase, from its soluble and native form into insoluble amyloid fibrils of the type observed in a range of pathological conditions. This was achieved by allowing slow growth in a solution containing moderate concentrations of trifluoroethano...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Chiti, Fabrizio, Webster, Paul, Taddei, Niccolò, Clark, Anne, Stefani, Massimo, Ramponi, Giampietro, Dobson, Christopher M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1999
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22338/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10097081/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.7.3590
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