Designing conditions for in vitro formation of amyloid protofilaments and fibrils
We have been able to convert a small α/β protein, acylphosphatase, from its soluble and native form into insoluble amyloid fibrils of the type observed in a range of pathological conditions. This was achieved by allowing slow growth in a solution containing moderate concentrations of trifluoroethano...
Guardat en:
| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22338/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10097081/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.7.3590 |
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