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Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences

Meganucleases cut long (>12 bp) unique sequences in genomes and can be used to induce targeted genome engineering by homologous recombination in the vicinity of their cleavage site. However, the use of natural meganucleases is limited by the repertoire of their target sequences, and considerable...

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Detalhes bibliográficos
Main Authors: Fajardo-Sanchez, Emmanuel, Stricher, François, Pâques, Frédéric, Isalan, Mark, Serrano, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367722/
https://ncbi.nlm.nih.gov/pubmed/18276641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn059
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