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A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells

Homologous gene targeting is the ultimate tool for reverse genetics, but its use is often limited by low efficiency. In a number of recent studies, site- specific DNA double-strand breaks (DSBs) have been used to induce efficient gene targeting. Engineering highly specific, dedicated DNA endonucleas...

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Bibliografische gegevens
Hoofdauteurs: Epinat, Jean-Charles, Arnould, Sylvain, Chames, Patrick, Rochaix, Pascal, Desfontaines, Dominique, Puzin, Clémence, Patin, Amélie, Zanghellini, Alexandre, Pâques, Frédéric, Lacroix, Emmanuel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2003
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC156710/
https://ncbi.nlm.nih.gov/pubmed/12771221
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