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Efficient gene targeting mediated by a lentiviral vector-associated meganuclease

Gene targeting can be achieved with lentiviral vectors delivering donor sequences along with a nuclease that creates a locus-specific double-strand break (DSB). Therapeutic applications of this system would require an appropriate control of the amount of endonuclease delivered to the target cells, a...

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Détails bibliographiques
Auteurs principaux: Izmiryan, Araksya, Basmaciogullari, Stéphane, Henry, Adrien, Paques, Frédéric, Danos, Olivier
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2011
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177226/
https://ncbi.nlm.nih.gov/pubmed/21715375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr524
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