Delivery of the Cre recombinase by a self-deleting lentiviral vector: Efficient gene targeting in vivo

The Cre recombinase (Cre) from bacteriophage P1 is an important tool for genetic engineering in mammalian cells. We constructed lentiviral vectors that efficiently deliver Cre in vitro and in vivo. Surprisingly, we found a significant reduction in proliferation and an accumulation in the G(2)/M phas...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pfeifer, Alexander, Brandon, Eugene P., Kootstra, Neeltje, Gage, Fred H., Verma, Inder M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC58750/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11553794/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.201415498
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!