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Delivery of the Cre recombinase by a self-deleting lentiviral vector: Efficient gene targeting in vivo
The Cre recombinase (Cre) from bacteriophage P1 is an important tool for genetic engineering in mammalian cells. We constructed lentiviral vectors that efficiently deliver Cre in vitro and in vivo. Surprisingly, we found a significant reduction in proliferation and an accumulation in the G(2)/M phas...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The National Academy of Sciences
2001
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC58750/ https://ncbi.nlm.nih.gov/pubmed/11553794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.201415498 |
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